| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats
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| Autores: |
Barbosa,Vanessa Santos de Arruda
Holanda,Maria de Carvalho Xavier
Silva,Roseane Pereira da
Oliveira,Daniel Pereira de
Silva Júnior,Maurício Ferreira da
Oliveira,Elias Herculano de
Spyrides,Maria Helena Constantino
Medeiros,Aldo Cunha
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| Data: |
2008-12-01
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| Ano: |
2008
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| Palavras-chave: |
Antiparasite
Radiopharmaceutical
Technetium-99m
Benznidazole
Biodistribution
Trypanosoma cruzi
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| Resumo: |
Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700028
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132008000700028
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.51 n.spe 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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